Category Archives: Publications

Series of papers on PDAC

A series of three papers appeared this week in which we contributed towards therapeutic strategies in pancreatic cancer. A nice summary of results from our collaborative efforts ongoing for quite some years. That all those were accepted within one week … Continue reading

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Paper on hexanematic order appeared in Nature Comm.

“Hexanematic crossover in epithelial monolayers depends on cell adhesion and cell density” Julia Eckert, Benoît Ladoux, René-Marc Mège, Luca Giomi & Thomas Schmidt Changes in tissue geometry during developmental processes are associated with collective migration of cells. Recent experimental and … Continue reading

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Integrin as prognostic marker

Integrin alpha-2 popped up in a screen of aggressive and chemoresistant PDAC cancers. In this study of Alessandro and Cecilia we validated the results we obtained in the RNA screen with various methods. Again we find a correlation between cell … Continue reading

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Molecule counting in STORM

We developed a novel methodology to count the number of molecules in a STORM image. That allowed us to address the stoichiometry of adhesion proteins in focal adhesions. It appeared that the stoichiometry in FAK is independent on the force … Continue reading

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From molecule to tissue.

Cell-cell and cell-matrix interactions are governed by interactions between individual molecules. But how does a tissue emerge from those localized and individual events? In this review we summarize our current understanding. Holding it together: when cadherin meets cadherin Arslan, F. … Continue reading

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