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Molecule counting in STORM
We developed a novel methodology to count the number of molecules in a STORM image. That allowed us to address the stoichiometry of adhesion proteins in focal adhesions. It appeared that the stoichiometry in FAK is independent on the force … Continue reading
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From molecule to tissue.
Cell-cell and cell-matrix interactions are governed by interactions between individual molecules. But how does a tissue emerge from those localized and individual events? In this review we summarize our current understanding. Holding it together: when cadherin meets cadherin Arslan, F. … Continue reading
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Pericyte mechanics.
Olga’s paper appeared in Stem Cell Reports, reporting on the particular mechanoresponse of pericytes, that might be related to their function. Fibronectin Patches as Anchoring Points for Force Sensing and Transmission in Human Induced Pluripotent Stem Cell-Derived Pericytes. Pericytes (PCs) … Continue reading
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Cells in Hypergravity .
Ever wondered how cells react when you fly them at 20g? Indeed they change their mechanical and other properties. This experiment, driven by Julia, is a ramp-up to our experiment flying on ISS. Hypergravity affects Cell Traction Forces of Fibroblasts … Continue reading
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Hemidesmosome mechanics, JCB 219, e201904137
Wang, W., A. Zuidema, L. te Molder, L. Nahidiazar, L. Hoekman, T. Schmidt, S. Coppola, and A. Sonnenberg. 2020. Hemidesmosomes modulate force generation via focal adhesions. The Journal of Cell Biology 219(2). [DOI] Abstract Hemidesmosomes are specialized cell-matrix adhesion structures … Continue reading
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